Effects of Boron-Containing Compounds on Liposoluble Hormone Functions

Boron-containing compounds (BCC), particularly boronic acids and derivatives, are being increasingly tested as diagnostic therapeutic agents. Some effects of BCC involve phenomena linked to the action steroid or thyroid hormones; among these, on muscle mass basal metabolism. Additionally, some toxicology reports mammals, including humans, sound an alert concerning damage several systems, which negative induction male infertility. Systemic local mechanisms explain changes in metabolism impaired fertility were collected presented. Then, we presented putative pharmacodynamic pharmacokinetic involved demonstrated these events. In addition, it is proposed that there adducts oxygenated with cis-diols fructose, essential source energy for sperm–cell motility, uncoupling sex hormone-binding globulin (SHBG) its ligands, modulation DNA synthetic rate. These share reactivity boron-containing key molecules. Moreover, data reporting no after administration included. Further studies required support clear role through events disrupt mammals. If such confirmed elucidated, advance could be useful design strategies avoiding toxicity administration, possibly designing regulators contraceptive drugs, other purposes. Boronic derivatives carboranes have been studied this field.